A missing peak in an HbA1c test result for a diabetic patient can happen for a few reasons.
Here are some of the most common culprits:
Interfering substances:
Hemoglobin variants: Certain abnormal types of hemoglobin (Hb), like those found in sickle cell disease or thalassemia, can interfere with the test and lead to falsely low or unreadable HbA1c results.
- Example
Source : Bio Rad D10 HbA1C Analyzer
- Example
Conditions affecting red blood cells:
Anemia: Conditions that shorten the lifespan of red blood cells, like hemolytic anemia, can lead to a lower HbA1c because there are fewer red blood cells available to be glycated (attached to sugar molecules).
Blood transfusions: Recent blood transfusions can dilute the patient's red blood cells, making it difficult to get an accurate HbA1c measurement.
Other factors:
Technical issues: Rarely, there might be issues with the laboratory equipment or test itself that can lead to an unreadable result.
Here's what to do if your HbA1c test shows no peak:
Don't rely solely on this test result. Discuss it with your doctor to understand if any of the factors mentioned above might be influencing the outcome.
Your doctor might recommend repeating the test or using an alternative method for measuring blood sugar control, such as fructosamine or self-monitoring of blood glucose.
Source : Dr. Md. Saroar Jahan RajibMBBS,BCS (Health), MD(Hematology)National Institute Cancer Research & HospitalMohakhali,Dhaka